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KMID : 0928320050050010037
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Korean Journal of Health Promotion and Disease Prevention
2005 Volume.5 No. 1 p.37 ~ p.44
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Interactions between mutations of p53 and K-ras genes in stomach cancer tissues, Helicobacter pylori infection, and IL-1B polymorphism
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Yoon Ho-Young
Song Young-Jin
Park Joo-Seung
Hyun Tai-Sun
Youn Sei-Jin
Kim Yong-Dae
Kang Jong-Won
Kim Heon
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Abstract
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Backgrounds: The aim of the study is to assess the effect of cigarette smoking, the IL-1B polymorphism, history of H. pylori infection on gastric cancer and to analyze the association between H. pylori infection and mutations of p53 and K-ras genes in gastric cancer tissue.
Methods: One hundred and ten gastric cancer patients and 220 age- and sex-matched controls were included in
this study. Information on the smoking habit was gathered, and the IL-1B genotype was identified for every subject. Mutations in the exons of p53 and K-ras genes were checked by sequencing. Relationships of cigarette smoking, IL-1B genotype, and anti-H. pylori IgG antibody with the risk of gastric cancer, and with mutations of the p53 and K-ras genes in gastric cancer tissue were statistically tested.
Results: The smoking prevalence was higher in cases than in controls, but cumulative smoking amount was
not. There was no significant difference in H. pylori infection rate and in IL-1B polymorphic distribution between cases and controls. Cigarette smoking and IL-1B polymorphism were not significantly associated with H. pylori infection. The mutation rates of p53 and K-ras genes in cancer tissue did not differ according to the smoking, IL-1B polymorphism or H. pylori infection in cases.
Conslusions: Smoking increases the risk of gastric cancer, but doest not that of H. pylori infection. H. pylori would not play a major role in the development of p53 or K-ras mutations. However, we cannot rule out the possibility that CagA(+) H. pylori is associated with the IL-1B polymorphism and p53 mutation.
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KEYWORD
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Gastric cancer, cigarette smoking, Helicobacter pylori, IL-1B, p53, K-ras.
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